| LDR | | 04664cmm u2200709Ii 4500 |
| 001 | | 000000321281 |
| 003 | | OCoLC |
| 005 | | 20230613110449 |
| 006 | | m d |
| 007 | | cr |n||||||||| |
| 008 | | 200224s2020 enk o 001 0 eng d |
| 019 | |
▼a 1142521498 |
| 020 | |
▼a 9780192596710
▼q (electronic bk.) |
| 020 | |
▼a 0192596713
▼q (electronic bk.) |
| 020 | |
▼a 9780191888793
▼q electronic book |
| 020 | |
▼a 0191888796
▼q electronic book |
| 020 | |
▼z 0198854501 |
| 020 | |
▼z 9780198854500 |
| 035 | |
▼a 2375977
▼b (N$T) |
| 035 | |
▼a (OCoLC)1141504579
▼z (OCoLC)1142521498 |
| 040 | |
▼a YDX
▼b eng
▼e rda
▼c YDX
▼d OH1
▼d YDXIT
▼d UKOUP
▼d OCLCF
▼d UBY
▼d EBLCP
▼d N$T
▼d 248032 |
| 043 | |
▼a e-uk--- |
| 049 | |
▼a MAIN |
| 050 | 4 |
▼a QH506
▼b .T46 2020 |
| 082 | 04 |
▼a 509.2241
▼2 23 |
| 100 | 1 |
▼a Thomas, J. M.
▼q (John Meurig),
▼e author. |
| 245 | 10 |
▼a Architects of structural biology :
▼b Bragg, Perutz, Kendrew, Hodgkin /
▼c John Meurig Thomas.
▼h [electronic resource] |
| 250 | |
▼a First edition. |
| 260 | |
▼a Oxford, United Kingdom ;
▼a New York, NY :
▼b Oxford University Press,
▼c 2020. |
| 300 | |
▼a 1 online resource |
| 336 | |
▼a text
▼b txt
▼2 rdacontent |
| 337 | |
▼a computer
▼b c
▼2 rdamedia |
| 338 | |
▼a online resource
▼b cr
▼2 rdacarrier |
| 500 | |
▼a Includes index. |
| 520 | |
▼a Designed for the non-specialist, the explanations and illustrations used here describe the work, personalities, collaborations, and idiosyncrasies of four of the most distinguished Nobel Laureates of the twentieth century. They exploited a discovery made over a century ago about the nature of X-rays, and thereby created a new branch of science. This enabled them to elucidate, in atomic detail, the structure and mode of action of molecules of the living world: enzymes, vitamins, and viruses, as well as antibiotics. Perutz and Kendrew, from their pioneering work using X-ray diffraction on haemoglobin and myoglobin, the proteins that transport and store oxygen in all animals, led them to establish in 1962 one of the most successful research centres ever - the Laboratory of Molecular Biology (LMB) in Cambridge. Medicines discovered there are used worldwide to treat leukaemia, arthritis, and other diseases. Their work also led to the creation in the United States of the Protein Data Bank that guides scientists in understanding the misfolding of proteins, which cause Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. This book is first a memoir of these scientists and their contemporaries, many of them friends of the author. Second, it is an insight into the great excitement associated with structural molecular biology, which directly informs our understanding of ourselves. Third, it describes how two renowned research centres in the United Kingdom - the LMB and the Davy-Faraday Research Laboratory - achieved iconic status. It also highlights the importance of the popularization of science, of which Bragg, Perutz, and Kendrew, as well as Dorothy Hodgkin (who solved the structures of penicillin and vitamin B12) were experts. |
| 588 | |
▼a Description based on online resource, title from PDF title page (Oxford Scholarship Online, viewed March 25, 2020). |
| 590 | |
▼a OCLC control number change |
| 600 | 10 |
▼a Bragg, William Henry,
▼d 1862-1942. |
| 600 | 10 |
▼a Perutz, Max F. |
| 600 | 10 |
▼a Kendrew, John C.
▼q (John Cowdery),
▼d 1917-1997. |
| 600 | 10 |
▼a Hodgkin, Dorothy,
▼d 1910-1994. |
| 600 | 17 |
▼a Bragg, William Henry,
▼d 1862-1942.
▼2 fast
▼0 (OCoLC)fst01860187 |
| 600 | 17 |
▼a Hodgkin, Dorothy,
▼d 1910-1994.
▼2 fast
▼0 (OCoLC)fst00432108 |
| 600 | 17 |
▼a Kendrew, John C.
▼q (John Cowdery),
▼d 1917-1997.
▼2 fast
▼0 (OCoLC)fst00107380 |
| 600 | 17 |
▼a Perutz, Max F.
▼2 fast
▼0 (OCoLC)fst00164750 |
| 610 | 20 |
▼a Laboratory of Molecular Biology
▼x History. |
| 648 | 7 |
▼a 1900-1999
▼2 fast |
| 650 | 0 |
▼a Scientists
▼z Great Britain
▼x History
▼y 20th century. |
| 650 | 0 |
▼a Molecular biology
▼x History
▼y 20th century. |
| 650 | 0 |
▼a Proteins
▼x Structure
▼x Research
▼x History
▼y 20th century. |
| 650 | 7 |
▼a Molecular biology.
▼2 fast
▼0 (OCoLC)fst01024734 |
| 650 | 7 |
▼a Scientists.
▼2 fast
▼0 (OCoLC)fst01108895 |
| 651 | 7 |
▼a Great Britain.
▼2 fast
▼0 (OCoLC)fst01204623 |
| 655 | 0 |
▼a Electronic books. |
| 655 | 7 |
▼a History.
▼2 fast
▼0 (OCoLC)fst01411628 |
| 776 | 08 |
▼c Original
▼z 0198854501
▼z 9780198854500
▼w (OCoLC)1112422797 |
| 856 | 40 |
▼3 EBSCOhost
▼u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=2375977 |
| 938 | |
▼a Oxford University Press USA
▼b OUPR
▼n EDZ0002180018 |
| 938 | |
▼a YBP Library Services
▼b YANK
▼n 301112840 |
| 938 | |
▼a ProQuest Ebook Central
▼b EBLB
▼n EBL6118438 |
| 938 | |
▼a EBSCOhost
▼b EBSC
▼n 2375977 |
| 990 | |
▼a 관리자 |
| 994 | |
▼a 92
▼b N$T |