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008210102s2020 dcua ob 000 0 eng
010 ▼a 2020949045
0167 ▼a 101774876 ▼2 DNLM
019 ▼a 1227692209
020 ▼a 9780309671163 ▼q (electronic bk.)
020 ▼a 0309671167 ▼q (electronic bk.)
020 ▼z 9780309671149
020 ▼z 0309671140
020 ▼z 9780309671132
020 ▼z 0309671132
035 ▼a 2742053 ▼b (N$T)
035 ▼a (OCoLC)1227386525 ▼z (OCoLC)1227692209
040 ▼a NLM ▼b eng ▼e rda ▼c NLM ▼d YDX ▼d N$T ▼d OCLCF ▼d UKAHL ▼d TXM ▼d EBLCP ▼d OCLCO ▼d YDX ▼d 248032
042 ▼a pcc
049 ▼a MAIN
05014 ▼a QH447 ▼b .H4758 2020
06000 ▼a QU 470
08204 ▼a 572.86 ▼2 23
24500 ▼a Heritable human genome editing / ▼c International Commission on the Clinical Use of Human Germline Genome Editing ; National Academy of Medicine ; National Academy of Sciences ; and the Royal Society. ▼h [electronic resource]
24630 ▼a Human genome
260 ▼a Washington, DC : ▼b The National Academies Press, ▼c [2020]
300 ▼a 1 online resource (1 PDF file (xviii, 219 pages)) : ▼b color illustrations.
336 ▼a text ▼b txt ▼2 rdacontent
337 ▼a computer ▼b c ▼2 rdamedia
338 ▼a online resource ▼b cr ▼2 rdacarrier
4901 ▼a Consensus study report
504 ▼a Includes bibliographical references.
5050 ▼a Intro -- FrontMatter -- Special Acknowledgments -- Foreword -- Contents -- Boxes and Figures -- Summary -- 1 Introduction -- 2 The State of the Science -- 3 Potential Applications of Heritable Human Genome Editing -- 4 A Translational Pathway to Limited and Controlled Clinical Applications of Heritable Human Genome Editing -- 5 National and International Governance of Heritable Human Genome Editing -- References -- Appendix A: Information Sources and Methods -- Appendix B: Commissioner Biographies -- Appendix C: Glossary -- Appendix D: Acronyms and Abbreviations -- Acknowledgment of Reviewers
520 ▼a "Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight."-- ▼c Publisher's website.
536 ▼a This activity was supported by Contract No. HHSN263201800029I / Order No. 75N98019F00852 from the U.S. National Institutes of Health, Grant No. 2019 HTH 009 from the Rockefeller Foundation, and Grant 218375/Z/19/Z from the Wellcome Trust, with additional support from the Royal Society of the United Kingdom, the Cicerone Endowment Fund of the U.S. National Academy of Sciences, and the NAM Initiatives Fund of the U.S. National Academy of Medicine. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.
588 ▼a Description based on online resource; title from digital title page (viewed on May 03, 2021).
590 ▼a Master record variable field(s) change: 050, 082
650 0 ▼a Human genome.
650 0 ▼a Gene editing.
650 0 ▼a Ethics.
65012 ▼a Gene Editing.
65012 ▼a Genome.
65022 ▼a Quantitative Trait, Heritable.
65022 ▼a Genomics ▼x methods.
650 7 ▼a Ethics. ▼2 fast ▼0 (OCoLC)fst00915833
650 7 ▼a Gene editing. ▼2 fast ▼0 (OCoLC)fst02000662
650 7 ▼a Human genome. ▼2 fast ▼0 (OCoLC)fst00963101
655 4 ▼a Electronic books.
7102 ▼a International Commission on the Clinical Use of Human Germline Genome Editing, ▼e issuing body.
77608 ▼i Print version: ▼a Society, The Royal ▼t Heritable Human Genome Editing ▼d Washington, D.C. : National Academies Press,c2021 ▼z 9780309671132
830 0 ▼a Consensus study report.
85640 ▼3 EBSCOhost ▼u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=2742053
938 ▼a EBSCOhost ▼b EBSC ▼n 2742053
938 ▼a YBP Library Services ▼b YANK ▼n 17163959
938 ▼a ProQuest Ebook Central ▼b EBLB ▼n EBL6426686
938 ▼a YBP Library Services ▼b YANK ▼n 301915094
938 ▼a Askews and Holts Library Services ▼b ASKH ▼n AH38277896
990 ▼a 관리자
994 ▼a 92 ▼b N$T