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020 ▼a 0691200254 ▼q electronic book
020 ▼a 9780691200255 ▼q (electronic bk.)
035 ▼a 2377008 ▼b (N$T)
035 ▼a (OCoLC)1154518403
037 ▼a 22573/ctvx52qpb ▼b JSTOR
040 ▼a EBLCP ▼b eng ▼e rda ▼c EBLCP ▼d UKAHL ▼d JSTOR ▼d YDXIT ▼d DEGRU ▼d OCLCF ▼d NOC ▼d YDX ▼d N$T ▼d 248032
049 ▼a MAIN
050 4 ▼a QP517.C45 ▼b P55 2020
08204 ▼a 571.74 ▼2 23
1001 ▼a Phillips, Rob, ▼e author.
24514 ▼a The Molecular Switch : ▼b Signaling and Allostery / ▼c Rob Phillips ; illustrated by Nigel Orme.
260 ▼a Princeton : ▼b Princeton University Press, ▼c [2020]
300 ▼a 1 online resource (437 p.)
336 ▼a text ▼b txt ▼2 rdacontent
337 ▼a computer ▼b c ▼2 rdamedia
338 ▼a online resource ▼b cr ▼2 rdacarrier
4900 ▼a Studies in physical biology
500 ▼a 4.4.1 Adaptation by Hand
5050 ▼a Cover -- Contents -- Preface -- PART I: THE MAKING OF MOLECULAR SWITCHES -- 1. It's An Allosteric World -- 1.1 The Second Secret of Life -- 1.2 The Broad Reach of the Allostery Concept -- 1.2.1 Sculpting Biochemistry via Allostery -- 1.2.2 One- and Two-Component Signal Transduction and the Two-State Philosophy -- 1.3 Reasoning about Feedback: The Rise of Allostery -- 1.3.1 The Puzzle -- 1.3.2 The Resolution of the Molecular Feedback Puzzle -- 1.3.3 Finding the Allosterome -- 1.4 Mathematicizing the Two-State Paradigm -- 1.4.1 Transcendent Concepts in Physics
5058 ▼a 1.4.2 One Equation to Rule Them All -- 1.5 Beyond the MWC Two-State Concept -- 1.5.1 Molecular Agnosticism: MWC versus KNF versus Eigen -- 1.6 On BeingWrong -- 1.7 Summary -- 1.8 Further Reading -- 1.9 References -- 2. The Allosterician's Toolkit -- 2.1 A Mathematical Microscope: Statistical Mechanics Preliminaries -- 2.1.1 Microstates -- 2.1.2 The Fundamental Law of Statistical Mechanics -- 2.1.3 The Dimensionless Numbers of Thermal Physics -- 2.1.4 Boltzmann and Probabilities -- 2.2 Case Study in Statistical Mechanics: Ligand-Receptor Binding
5058 ▼a 2.2.1 Ligand Binding and the Lattice Model of Solutions -- 2.3 Conceptual Tools of the Trade: Free Energy and Entropy -- 2.3.1 Resetting Our Zero of Energy Using the Chemical Potential -- 2.4 The MWC Concept in Statistical Mechanical Language -- 2.5 Cooperativity and Allostery -- 2.5.1 Cooperativity and Hill Functions -- 2.5.2 Cooperativity in the MWC Model -- 2.6 Internal Degrees of Freedom and Ensemble Allostery -- 2.7 Beyond Equilibrium -- 2.8 Summary -- 2.9 Further Reading -- 2.10 References -- PART II: THE LONG REACH OF ALLOSTERY -- 3. Signaling at the Cell Membrane: Ion Channels
5058 ▼a 3.1 How Cells Talk to the World -- 3.2 Biological Processes and Ion Channels -- 3.3 Ligand-Gated Channels -- 3.4 Statistical Mechanics of the MWC Channel -- 3.5 Data Collapse, Natural Variables, and the Bohr Effect -- 3.5.1 Data Collapse and the Ion-Channel Bohr Effect -- 3.6 Rate Equation Description of Channel Gating -- 3.7 Cyclic Nucleotide-Gated Channels -- 3.8 Beyond the MWC Model in Ion Channelology -- 3.8.1 Conductance Substates and Conformational Kinetics -- 3.8.2 The Koshland-Ne?methy-Filmer Model Revealed -- 3.8.3 Kinetic Proliferation -- 3.8.4 The Question of Inactivation -- 3.9 Summary
5058 ▼a 3.10 Further Reading -- 3.11 References -- 4. How Bacteria Navigate the World around Them -- 4.1 Bacterial Information Processing -- 4.1.1 Engelmann's Experiment and Bacterial Aerotaxis -- 4.1.2 Love Thy Neighbors: Signaling between Bacteria -- 4.2 Bacterial Chemotaxis -- 4.2.1 The Chemotaxis Phenomenon -- 4.2.2 Wiring Up Chemotaxis through Molecular Switching -- 4.3 MWC Models of Chemotactic Response -- 4.3.1 MWC Model of Chemotaxis Receptor Clusters -- 4.3.2 Heterogenous Clustering -- 4.3.3 Putting It All Together by Averaging -- 4.4 The Amazing Phenomenon of Physiological Adaptation
520 ▼a A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery--a powerful explanation of how molecules function across all biological domains--can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.
588 ▼a Description based on online resource; title from digital title page (viewed on September 16, 2020).
590 ▼a Added to collection customer.56279.3
650 0 ▼a Cellular signal transduction.
650 0 ▼a Cellular control mechanisms.
650 7 ▼a SCIENCE / Life Sciences / Biophysics. ▼2 bisacsh
650 7 ▼a Cellular control mechanisms ▼2 fast ▼0 (OCoLC)fst00850278
650 7 ▼a Cellular signal transduction ▼2 fast ▼0 (OCoLC)fst00850288
655 4 ▼a Electronic books.
77608 ▼i Print version: ▼a Phillips, Rob ▼t The Molecular Switch : Signaling and Allostery ▼d Princeton : Princeton University Press,c2020 ▼z 9780691200248
85640 ▼3 EBSCOhost ▼u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=2377008
938 ▼a YBP Library Services ▼b YANK ▼n 16665712
938 ▼a De Gruyter ▼b DEGR ▼n 9780691200255
938 ▼a Askews and Holts Library Services ▼b ASKH ▼n AH37414671
938 ▼a ProQuest Ebook Central ▼b EBLB ▼n EBL6195824
938 ▼a EBSCOhost ▼b EBSC ▼n 2377008
990 ▼a 관리자
994 ▼a 92 ▼b N$T