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Functionalized Acyclic Cucurbit[N]URIL Molecular Containers as Reversal Agents for Drugs

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자료유형	E-Book
개인저자	Ganapati, Shweta.
단체저자명	University of Maryland, College Park. Chemistry.
서명/저자사항	Functionalized Acyclic Cucurbit[N]URIL Molecular Containers as Reversal Agents for Drugs.
발행사항	[S.l.] : University of Maryland, College Park., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	350 p.
소장본 주기	School code: 0117.
ISBN	9780355829778
일반주기	Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. Adviser: Lyle Isaacs.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	The study of molecular containers has a prominent place in the scientific literature with many applications, including drug reversal. The clinical use of the cyclodextrin based reversal agent Bridion(TM) has greatly improved the post-operative s
요약	Chapter 1 introduces molecular containers, CB[n], and reports the use of the acyclic CB[n] known as Calabadion 2 as a broad spectrum reversal agent for NMBAs in rats. It also proposes the potential use of molecular containers as reversal agents
요약	Chapter 2 establishes that Calabadion 2 displays good to high levels of selectivity toward the NMBAs rocuronium, vecuronium, and cisatracurium both in vitro and based on simulations designed to capture the essence of the biological system. The e
요약	Chapter 3 establishes that CB[n] based molecular containers - Calabadion 1, Calabadion 2, and CB[7] display higher affinities than p-sulfocalix[4]arene and HP-beta-cyclodextrin toward a panel of illicit drugs for which there are currently no USF
요약	Chapter 4 discusses the synthesis and molecular recognition properties of three new acyclic CB[n] hosts IV-2a -- IV-2c which incorporate alkyl linkers of varying lengths- ethyl, hexyl, and decyl
일반주제명	Chemistry. Organic chemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-10B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996643