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Mechanism of Protein Acetylation in Mitochondria
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Baeza, Josue. |
| 단체저자명 | The University of Wisconsin - Madison. Biomolecular Chemistry. |
| 서명/저자사항 | Mechanism of Protein Acetylation in Mitochondria. |
| 발행사항 | [S.l.] : The University of Wisconsin - Madison., 2017 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2017 |
| 형태사항 | 206 p. |
| 소장본 주기 | School code: 0262. |
| ISBN | 9780438024113 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: John M. Denu. |
| 요약 | Reversible N-epsilon-acetylation has emerged as a widespread and regulatory modification throughout the cell. First identified on N-terminal histone tails over 50 years ago, acetylation has now been identified on over 36,000 lysine sites on orga |
| 요약 | In mitochondria, acetylation generally acts as an inhibitory modification, altering protein interactions, lowered enzymatic activity and mislocalization of mitochondrial proteins. In this case, acetylation acts as a rheostat, modulating the degr |
| 요약 | The mechanism of mitochondrial protein acetylation remains unknown. While there is a wealth of data supporting a dynamic and regulatory role for acetylation within mitochondria, there is very little evidence for an enzyme-catalyzed reaction. How |
| 요약 | Throughout my thesis research, I have utilized chemical, biochemical, proteomic, and cellular studies to characterize protein acetylation. Specifically, I developed a mass spectrometry based approach to directly quantify lysine acetylation stoic |
| 요약 | Chapter 1 introduces lysine acetylation, the various processes controlling cellular levels including enzymatic and nonenzymatic, and why quantifying acetylation stoichiometry is needed. Chapter 2 discusses the mass spectrometry based method used |
| 일반주제명 | Biochemistry. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-10B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14996556 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028887 | 574 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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