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Biomedical Applications and Strategies Using Boronic Acids

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자료유형	E-Book
개인저자	Smith, Thomas P.
단체저자명	The University of Wisconsin - Madison. Chemistry.
서명/저자사항	Biomedical Applications and Strategies Using Boronic Acids.
발행사항	[S.l.] : The University of Wisconsin - Madison., 2016
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2016
형태사항	358 p.
소장본 주기	School code: 0262.
ISBN	9780438159518
일반주기	Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. Adviser: Ronald T. Raines.
요약	Boronic acids have been shown to interact with biological molecules including carbohydrates and reactive oxygen species (ROS). This variety of biological targets is due to the unique reactivity of boron that, within a physiological pH range, can
요약	The development of therapeutic proteins is generating considerable interest. This interest is due to the high selectivity of proteins for a target and the high enzymatic activity a protein-based therapeutic can possess. There are, however, a num
요약	In chapter 2, I describe the development of a discreet, small-molecule boronic acid-based delivery strategy for the delivery of native protein into the cytosol of a cell. This was accomplished by appending a specialized boronic acid directly to
요약	Another challenge with biologic therapeutics is overcoming the potential pleiotropic nature of the particular protein or enzyme. This challenge is explicit in the use of angiogenin (ANG) as a potential treatment of amyotrophic lateral sclerosis
요약	In chapter 3, I highlight a specific masking strategy that silences the catalytic activity of ANG under normal physiological conditions. When exposed to reactive oxygen species (ROS) leading to oxidative stress, this mask is removed, and catalyt
요약	In ALS, the up-regulation of ROS in the central nervous system (CNS) is primarily responsible for the motor neuron degeneration characteristic of the disease. The presence of a boronic acid-masking agent engenders ANG with pro-drug characteristi
요약	Boronic acids have also been utilized as important functional groups in medicinal chemistry. For example, VelcadeRTM (bortezomib), is a first-in-class boronic acid-containing protease inhibitor and the first boronic acid drug to be approved by t
요약	In chapter 4, I discuss the development and characterization of a targeted library of small-molecule boronic acids that bind to the thyroxin (T 4) binding pockets and strongly inhibit fibril formation in both wild-type and a common disease varia
일반주제명	Biochemistry. Chemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-11B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996547