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Chemical Synthesis and Biological Evaluation of Novel Indole-containing Heterocycles

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개인저자Winston-Mcpherson, Gabrielle Noel.
단체저자명The University of Wisconsin - Madison. Pharmaceutical Sciences.
서명/저자사항Chemical Synthesis and Biological Evaluation of Novel Indole-containing Heterocycles.
발행사항[S.l.] : The University of Wisconsin - Madison., 2016
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2016
형태사항226 p.
소장본 주기School code: 0262.
ISBN9780438024090
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Weiping Tang.
요약The Tang lab has developed several methodologies to generate indole containing heterocycles. These reactions are known as indole annulations. Considering that indole is present in several bioactive small molecules, we have studied the activity o
요약Cardiovascular diseases (CVD) are one of the leading causes of death in humans world wide. Strongly associated with CVD are high low-density lipoprotein cholesterol (LDL-C) levels. This condition is known as hypercholesterolemia. Proprotein conv
요약In partnership with Eli Lilly's Open Innovation Drug Discovery (OIDD) program, we have identified novel indole-containing heterocycles that reduce PCSK9 levels at low micromolar concentrations. Notably, our reported platinum catalyzed indole ann
요약The aryl hydrocarbon receptor (AhR) has emerged as a target with therapeutic potential. It has been postulated that AhR may be a target for the treatment of benign prostatic hyperplasia, undesired immune response during organ transplantation, in
일반주제명Cellular biology.
Biochemistry.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996509

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