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Toll-like Receptor 4 Regulates Intraspinal and Peripheral Responses after Spinal Cord Injury

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개인저자Church, Jamie Stoddard.
단체저자명The Ohio State University. Neuroscience.
서명/저자사항Toll-like Receptor 4 Regulates Intraspinal and Peripheral Responses after Spinal Cord Injury.
발행사항[S.l.] : The Ohio State University., 2016
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2016
형태사항256 p.
소장본 주기School code: 0168.
ISBN9780438310261
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Dana McTigue.
요약Traumatic spinal cord injury (SCI) disrupts not only tissue within the central nervous system (CNS), but homeostatic processes in the periphery as well. Macrophages are immune cells that accumulate in the spinal cord lesion site and in periphera
요약In the damaged spinal cord DAMPs initiate secondary injury processes including apoptosis and inflammation. Acutely, cells of the oligodendrocyte (OL) lineage (OLs and their progenitor cells, OPCs) are lost, but this extensive glial cell loss is
요약Anemia and pressure ulcers are two common iron-related comorbidities with SCI. Because TLR4 is an innate immune receptor and its signaling in macrophages regulates systemic iron during pathogen invasion we investigated whether TLR4 signaling inf
요약In conclusion, my graduate work shows that intraspinal TLR4 signaling alters macrophage iron regulation and myelin debris phagocytosis, and influences each stage of OL lineage cell progression in the healthy adult CNS and/or after SCI and lysole
일반주제명Neurosciences.
Immunology.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15001367

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