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Mechanistic Investigation of Activation of the Innate Immune Sensor PKR by Various Levels and Types of RNA Structure

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자료유형	E-Book
개인저자	Hull, Chelsea M.
단체저자명	The Pennsylvania State University. Chemistry.
서명/저자사항	Mechanistic Investigation of Activation of the Innate Immune Sensor PKR by Various Levels and Types of RNA Structure.
발행사항	[S.l.] : The Pennsylvania State University., 2016
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2016
형태사항	229 p.
소장본 주기	School code: 0176.
ISBN	9780438135024
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
요약	The innate immune response is the first line of defense against invading pathogens, thus it is of very critical importance to human health and medicine. There are many dangerous pathogens and microorganisms that threaten the human cell at all ti
요약	The protein kinase PKR is an essential protein in the innate immune response that upon recognition of pathogenic patterns is activated and eventually leads to apoptosis of this infected cell. PKR recognizes molecular patterns through unique path
요약	RNA molecules can adopt an array of structures and perform many different functions in the cell. It is important to understand both sides of the interaction between PKR and RNA because they are both functional molecules. Some pathogens are not r
요약	Much is already known about how PKR recognizes pathogenic RNA from viruses, but recently PKR has been shown to be activated in cells infected with RNA from bacteria. There are many levels of RNA structure found in the bacterial transcriptome whe
요약	I also expanded this into a detailed mechanistic study that different types of functional bacterial RNAs with extensive tertiary structure activate PKR including a riboswitch, a riboswitch-ribozyme, and a ribozyme. I showed that these bacterial
요약	Taking a step back and investigating PKR's interaction with RNA at the primary and secondary levels of RNA structure led to some findings that helped us understand how PKR can detect a broad range of RNA structure. At the primary level, our lab
일반주제명	Chemistry. Biochemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T15000668