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Novel Molecular Mechanisms of Signal Sensing and Transduction in Bacterial Chemotaxis

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개인저자Muok, Alise Renee.
단체저자명Cornell University. Biology.
서명/저자사항Novel Molecular Mechanisms of Signal Sensing and Transduction in Bacterial Chemotaxis.
발행사항[S.l.] : Cornell University., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항117 p.
소장본 주기School code: 0058.
ISBN9780438027282
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Brian R. Crane.
요약Bacterial chemotaxis is a behavior bacteria exhibit to alter their motility in response to their chemical environment. The underlying sensory pathway responsible for this movement involves transmembrane receptors called methyl accepting chemotax
요약In this dissertation, I present structural and activities studies of various proteins involved in bacterial chemotaxis. In particular, I focus on elucidating the structural changes that occur in the dimeric histidine kinase CheA when it switches
요약In addition, I have determined the role of a previously uncharacterized protein whose gene is often found next to those for cytoplasmic receptors. We have named this new chemotaxis protein ODP1 for Oxygen Di-iron Protein and I have extensively
요약Finally, I have developed a new method for spin-labeling proteins for EPR experiments. Specifically, I have synthesized and isolated an analog of ADP (ADP-beta-S-SL) that is covalently attached to a nitroxide spin label and can hence be reconsti
요약In summary, my work has provided new insights into the domain rearrangements that occur in CheA due to receptor mediated modulation. Additionally, I've characterized a new chemotaxis sensor protein that is responsible for monitoring intracellula
일반주제명Biochemistry.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14998362

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