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Structural Elucidation of Gas-Phase Peptide Ions by Tandem Mass Spectrometry and Molecular Dynamics Simulations

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개인저자Nguyen, Huong Thi Huynh.
단체저자명University of Washington. Chemistry.
서명/저자사항Structural Elucidation of Gas-Phase Peptide Ions by Tandem Mass Spectrometry and Molecular Dynamics Simulations.
발행사항[S.l.] : University of Washington., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항247 p.
소장본 주기School code: 0250.
ISBN9780438173521
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Frantisek Turecek.
요약The invention of the mass spectrometer has enabled scientists to discover numerous fascinating reactive gas-phase chemical species such as peptide cation radicals. The generation of these radicals can be accomplished via several methods includin
요약There are several methods available for probing the conformational structures of gas-phase ions such as collision-induced dissociation (CID), ion mobility (IM), infrared multiphoton dissociation (IRMPD), and UV-Vis photodissociation (UVPD). CID
요약In the first part of this work, which includes Chapters 2--5, the electronic structures of ETD-formed z-fragment ions were studied in detail using tandem mass spectrometry and molecular dynamics simulations. Chapter 2 investigates the photoreact
요약In a further attempt to investigate the 3D structures of peptide ions in the gas phase, we also explored the chemistry of diazirine as a way to freeze the conformations of the ion before subjecting it to structural analysis. Diazirine has been u
요약In part II of this work, which includes Chapter 6, the chemistry of diazirines was implemented to study non-covalent interactions of peptide complexes generated in the gas phase. Specifically, we incorporated diazirine-tagged amino acids (photol
일반주제명Chemistry.
Analytical chemistry.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14997365

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