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Many Facets of PNPase - Uncovering the Role of PNPase in the Mitochondria
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Shimada, Eriko Christine. |
| 단체저자명 | University of California, Los Angeles. Molecular Biology 0573. |
| 서명/저자사항 | Many Facets of PNPase - Uncovering the Role of PNPase in the Mitochondria. |
| 발행사항 | [S.l.] : University of California, Los Angeles., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 150 p. |
| 소장본 주기 | School code: 0031. |
| ISBN | 9780355803310 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-08(E), Section: B.
Adviser: Michael A. Teitell. |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | PNPase is a conserved 3'-5' exoribonuclease localized in the mammalian mitochondria. Its expression is essential for embryonic development and mitochondrial homeostasis. PNPase has been recently implicated in regulating mitochondrial RNA import. |
| 요약 | In order to further study the role of PNPase, we attempted to create a knockout cell line by adjusting the culture conditions to allow cells to survive without functional mitochondria. Interestingly, the resulting cell lines did not have any mit |
| 요약 | Finally, we characterized endogenous RNA targets of PNPase, its effect on steady state levels of mitochondrial RNA when PNPase expression is knocked down, and its interaction partners. We find that PNPase binds all mitochondrial tRNAs, mRNAs and |
| 일반주제명 | Molecular biology. Developmental biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-08B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14997164 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00026584 | 574 | 가야대학교// | 대출가능 |
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