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Quantifying and Modeling Radiation Therapy-induced Ventilation Changes and Investigating the Robustness of 4DCT-based Functional Avoidance

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개인저자Patton, Taylor J.
단체저자명The University of Wisconsin - Madison. Medical Physics.
서명/저자사항Quantifying and Modeling Radiation Therapy-induced Ventilation Changes and Investigating the Robustness of 4DCT-based Functional Avoidance.
발행사항[S.l.] : The University of Wisconsin - Madison., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항151 p.
소장본 주기School code: 0262.
ISBN9780438354586
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: John E. Bayouth.
요약Four-dimensional computed tomography-based ventilation is a developing method for estimating the lung function of patients. The response of 4DCT-based ventilation to radiation therapy (RT) has remained largely uncharacterized. The purpose of thi
요약Pre-RT and post-RT ventilation estimations were acquired, and the voxel-wise response of the post-RT ventilation to dose and pre-RT ventilation was determined. High-dose regions sustained more ventilation decline than low-dose regions. Increased
요약A polynomial regression model was created using pre-RT ventilation and dose to predict post-RT ventilation. This model showed significant predictive power on the cross-validation dataset as measured by gamma pass rates. The model was applied to
요약Predictive models were created to include the average heart dose and average lobe dose using linear regression and regression neural networks. The linear regression model including heart and lobe dose had the highest predictive power as measured
요약The impact of respiratory motion on functional avoidance was investigated using three representative dose distributions. The worst-case scenario dose distribution represented the patient at end-inspiration for the entirety of treatment. However,
일반주제명Medical imaging.
Physics.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15001157

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