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Biochemical and Therapeutic Characterization of the Cell-Penetrating Autoantibody 3E10

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자료유형	E-Book
개인저자	Turchick, Audrey Lauren.
단체저자명	Yale University.
서명/저자사항	Biochemical and Therapeutic Characterization of the Cell-Penetrating Autoantibody 3E10.
발행사항	[S.l.] : Yale University., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	130 p.
소장본 주기	School code: 0265.
ISBN	9780438194984
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: Peter M. Glazer.
요약	Despite advances in diagnostic and therapeutic approaches, cancer continues to be a leading cause of death worldwide, and the need for a better understanding of the molecular mechanisms underlying the initiation and progression of cancer still r
요약	One new anti-cancer agent of interest is 3E10, a unique cell-penetrating, anti-DNA autoantibody. 3E10 by itself is considered non-toxic to normal cells, but has been shown to inhibit homology directed repair (HDR). This had been attributed to 3E
요약	Prior work has shown that treatment with 3E10 alone can selectively kill cells with genetic mutations that lead to abnormal DNA repair. For example, 3E10 has been shown to be synthetically lethal in BRCA2 deficient human cancer cells. Recent fin
요약	Further, the cell penetrating ability of 3E10's scFv has led to the use of 3E10 as a delivery agent for peptides or additional scFvs for therapeutic approaches. One such example is the conjugation of the 3E10 scFv to the scFv of 3G5. 3G5 is a mo
요약	The 3E10-3G5 bispecific antibody retains the ability to penetrate cells to a similar extent of the 3E10 scFv alone. Moreover, 3E10-3G5 was shown to impair the growth of a variety of melanoma cells with aberrant MDM2 expression both in vitro and
요약	Because NHEJ is a critical repair pathway for maintaining genomic integrity, we hypothesize that the cytotoxicity observed in the melanoma cells is likely due to 3E10-3G5's inhibition of NHEJ. 3E10-3G5's ability to inhibit MDM2 may lead to p53 r
일반주제명	Genetics. Oncology. Biochemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T15000868