가야대학교 분성도서관

상단 글로벌/추가 메뉴

회원 로그인

주메뉴

: • 전체검색; • 단행본; • 정기간행물; • 학위논문; • 비도서; • 특정번호 검색; • 기사색인; • 학습연구지원; • 지정도서

: • 전자자원통합검색; • 해외 WEB DB; • E-Book; • E-Learning; • 국내 WEB DB; • 인터넷검색

: • 대출현황조회/연장; • 예약현황조회/취소; • 희망도서; • 내서재; • 나의서평; • 나의태그; • 나의위젯; • RSS; • SDI; • 개인정보관리

: • 공지사항; • FAQ; • Q&A 일반·학술; • 신착/인기 도서; • 학위논문온라인제출; • 외부인 이용안내; • 설문조사

: • 도서관 소개; • 연혁; • 현황; • 이용안내; • 찾아오시는 길

자료검색

Home
상세정보

상세정보

검색결과 돌아가기

부가기능

MARC보기

Biochemical and Therapeutic Characterization of the Cell-Penetrating Autoantibody 3E10

상세 프로파일

상세정보
자료유형	E-Book
개인저자	Turchick, Audrey Lauren.
단체저자명	Yale University.
서명/저자사항	Biochemical and Therapeutic Characterization of the Cell-Penetrating Autoantibody 3E10.
발행사항	[S.l.] : Yale University., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	130 p.
소장본 주기	School code: 0265.
ISBN	9780438194984
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: Peter M. Glazer.
요약	Despite advances in diagnostic and therapeutic approaches, cancer continues to be a leading cause of death worldwide, and the need for a better understanding of the molecular mechanisms underlying the initiation and progression of cancer still r
요약	One new anti-cancer agent of interest is 3E10, a unique cell-penetrating, anti-DNA autoantibody. 3E10 by itself is considered non-toxic to normal cells, but has been shown to inhibit homology directed repair (HDR). This had been attributed to 3E
요약	Prior work has shown that treatment with 3E10 alone can selectively kill cells with genetic mutations that lead to abnormal DNA repair. For example, 3E10 has been shown to be synthetically lethal in BRCA2 deficient human cancer cells. Recent fin
요약	Further, the cell penetrating ability of 3E10's scFv has led to the use of 3E10 as a delivery agent for peptides or additional scFvs for therapeutic approaches. One such example is the conjugation of the 3E10 scFv to the scFv of 3G5. 3G5 is a mo
요약	The 3E10-3G5 bispecific antibody retains the ability to penetrate cells to a similar extent of the 3E10 scFv alone. Moreover, 3E10-3G5 was shown to impair the growth of a variety of melanoma cells with aberrant MDM2 expression both in vitro and
요약	Because NHEJ is a critical repair pathway for maintaining genomic integrity, we hypothesize that the cytotoxicity observed in the melanoma cells is likely due to 3E10-3G5's inhibition of NHEJ. 3E10-3G5's ability to inhibit MDM2 may lead to p53 r
일반주제명	Genetics. Oncology. Biochemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T15000868