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Synthetic Studies on the Marineosins and Other Related Complex Prodiginines

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개인저자Allred, Tyler Keith.
단체저자명University of California, Los Angeles. Chemistry 0153.
서명/저자사항Synthetic Studies on the Marineosins and Other Related Complex Prodiginines.
발행사항[S.l.] : University of California, Los Angeles., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항526 p.
소장본 주기School code: 0031.
ISBN9780438173040
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Patrick G. Harran.
요약Chapter One provides an overview of complex prodiginine alkaloids: streptorubin, roseophilin, and the marineosins. This includes a brief discussion of the prototypical structural features of the prodiginine class of natural products, their isola
요약We have developed a unique method of constructing the pyrrolophane core via a late stage phosphoryl-transfer mediated macroaldolization, which was utilized in the production of roseophilin. Chapter Two chronicles our efforts to adapt this approa
요약Chapter Three discusses in detail our efforts to capitalize on the electron rich nature of the prodiginine core to engage a reactive functionality on the aliphatic chain and induce macrocyclization. Initial efforts were aimed at photoinduced ele
요약Chapter Four details our efforts to utilize the reactivity discovered in model system studies, which culminated in the synthesis of marineosin A. The photoinduced rearrangement of pyridinophane N-oxides proved particularly powerful in the produc
요약The readily apparent utility of the photoinduced rearrangement methodology caused us to revisit roseophilin. Chapter Five presents how the aforementioned rearrangement allows for facile access to the roseophilin pyrrolophane, which can be readil
일반주제명Organic chemistry.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14999590

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