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The Role of 12-Lipoxygenase in the Regulation of Platelet Function
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Yeung, Jennifer. |
| 단체저자명 | University of Michigan. Pharmacology. |
| 서명/저자사항 | The Role of 12-Lipoxygenase in the Regulation of Platelet Function. |
| 발행사항 | [S.l.] : University of Michigan., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 281 p. |
| 소장본 주기 | School code: 0127. |
| ISBN | 9780438125681 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Michael Allan Holinstat. |
| 요약 | Platelets are small, anucleated cellular fragments derived from the megakaryocytes of the bone marrow. These small cellular fragments have a specialized role in maintaining hemostasis, a process that prevents blood loss, through the initiation o |
| 요약 | Platelet 12-lipoxygenase (12-LOX), an oxygenase principally found to convert freed polyunsaturated fatty acids (PUFA) substrates from the membrane phospholipids following cellular stimulation, was identified to be a potential target for regulati |
| 요약 | Additionally, the role of 12-LOX in immune-mediated platelet activation was also investigated in this thesis work. One form of immune-mediated platelet activation or thrombosis is heparin-induced thrombocytopenia and thrombosis (HITT), a life-th |
| 요약 | 12-LOX predominantly generates 12(S)-HETE, an oxylipin or metabolite, from arachidonic acid (AA), since this is the most abundant o-6 PUFA found in the lipid bilayer of cells. Dietary supplementation of plant- or fish-based oils can alter and en |
| 일반주제명 | Pharmacology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15000470 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00025125 | DP 615 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출불가(별치) |
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