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Mixed Signals: Regulation of Host Metabolism by an Intracellular Bacterial Pathogen

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개인저자De Leon, Justin A.
단체저자명University of California, Berkeley. Molecular & Cell Biology.
서명/저자사항Mixed Signals: Regulation of Host Metabolism by an Intracellular Bacterial Pathogen.
발행사항[S.l.] : University of California, Berkeley., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항59 p.
소장본 주기School code: 0028.
ISBN9780438078444
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Russell E. Vance.
요약A hallmark of all pathogens is an ability to acquire nutrients from hosts. In order to do this, pathogens must overcome both the tight regulation of host nutrients and the host defense mechanisms deployed to protect these nutrients.
요약In the introductory chapter of this dissertation, I begin with a discussion of innate immunity. I discuss the now appreciated view of the innate immune system as a sensor of patterns of pathogenesis. I then argue, based on our studies in Legione
요약In chapter two, I provide experimental evidence that nutrient acquisition is a pattern of pathogenesis. I discuss my work describing how L. pneumophila alters a key metabolic signaling pathway, the mechanistic target of rapamycin complex 1 (mTOR
요약I then close with a perspective chapter that describes the additional questions my work has given rise to and the state of the bacterial molecular pathogenicity field as a whole.
일반주제명Microbiology.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996742

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