가야대학교 분성도서관

상단 글로벌/추가 메뉴

회원 로그인

주메뉴

: • 전체검색; • 단행본; • 정기간행물; • 학위논문; • 비도서; • 특정번호 검색; • 기사색인; • 학습연구지원; • 지정도서

: • 전자자원통합검색; • 해외 WEB DB; • E-Book; • E-Learning; • 국내 WEB DB; • 인터넷검색

: • 대출현황조회/연장; • 예약현황조회/취소; • 희망도서; • 내서재; • 나의서평; • 나의태그; • 나의위젯; • RSS; • SDI; • 개인정보관리

: • 공지사항; • FAQ; • Q&A 일반·학술; • 신착/인기 도서; • 학위논문온라인제출; • 외부인 이용안내; • 설문조사

: • 도서관 소개; • 연혁; • 현황; • 이용안내; • 찾아오시는 길

자료검색

Home
상세정보

상세정보

검색결과 돌아가기

부가기능

MARC보기

Molecular Insight into the Structure, Function, and Regulation of Bile Acid Transport

상세 프로파일

상세정보
자료유형	E-Book
개인저자	Czuba, Lindsay Christine.
단체저자명	University of Maryland, Baltimore. Pharmaceutical Sciences.
서명/저자사항	Molecular Insight into the Structure, Function, and Regulation of Bile Acid Transport.
발행사항	[S.l.] : University of Maryland, Baltimore., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	183 p.
소장본 주기	School code: 0373.
ISBN	9780355591248
일반주기	Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B. Adviser: Peter W. Swaan.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	The human Apical Sodium-dependent Bile Acid Transporter (SLC10A2), also known as hASBT, plays an integral role in the enterohepatic circulation of bile acid and cholesterol homeostasis. As a member of the solute carrier family of membrane transp
요약	Limiting the development of such therapeutics, is an incomplete understanding of hASBT's structure. Extensive biochemical and mutagenesis studies for hASBT support a seven transmembrane model. Yet conflicting structures have emerged with the elu
요약	In this work we provide novel molecular insight into the structure, function, and regulation of human ASBT. We contrasted the biochemical, inhibitory, and evolutionary attributes of nmAsbt, yfAsbt, and hASBT and identified their critical differe
요약	Additionally, we characterized the role of tyrosine phosphorylation in regulating the functional expression and stability of hASBT. We identified Src family kinases as critical modulators and provide support for hASBT's regulation by phosphatase
요약	Finally, we have optimized the biological sample preparation methods and have significantly increased the purity of hASBT samples. When coupled with mass spectrometry analysis, these methods will identify critical proteoforms of hASBT and facili
일반주제명	Pharmaceutical sciences.
언어	영어
기본자료 저록	Dissertation Abstracts International79-05B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996722