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Model systems in biology : history, philosophy, and practical concerns / [electronic resource]

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자료유형E-Book
개인저자Striedter, Georg F., 1962-, author.
서명/저자사항Model systems in biology :history, philosophy, and practical concerns /Georg Striedter.[electronic resource]
형태사항1 online resource (1 volume)
소장본 주기Added to collection customer.56279.3
ISBN9780262370028
0262370026


서지주기Includes bibliographical references and index.
내용주기Intro -- Contents -- Preface -- 1. Crises in Biomedical Research -- 1.1 The Translatability Crisis -- 1.2 The Replicability Crisis -- 1.3 Reckoning with Biological Variation -- 1.4 Which Model Is "Best"? -- 1.5 This Book's Approach and Organization -- 2. Philosophy of Models in Biology -- 2.1 Abstract Models -- 2.2 Material Models -- 2.3 Assumptions about Model Fidelity -- 2.4 Dealing with Biological Complexity -- 2.5 Animal Welfare and Cognitive Dissonance -- 2.6 Comparative Biology and August Krogh Revisited -- 3. A History of Animal Models -- 3.1 Eclectic Beginnings of Biology
3.2 Early Experimental Medicine: Research on Pet Species -- 3.3 Fruit Flies: The First Supermodel -- 3.4 Laboratory Rats: The First Standardized Mammals -- 3.5 Laboratory Mice: From Cancer Fighter to Model Organism -- 3.6 Nonhuman Primates -- 3.7 The Rest of the Menagerie -- 3.8 Model System Ecology -- 4. A History of in Vitro Models -- 4.1 Microbial Models -- 4.2 Cell and Tissue Culture Models -- 4.3 Alternative Models in Toxicology -- 4.4 Model Ecology Revisited -- 5. Models and Therapies: Infectious Diseases, Cardiovascular Disease, and Cancer -- 5.1 Infectious Diseases
5.2 Cardiovascular Diseases -- 5.3 Cancers -- 5.4 Patterns of Model Use -- 6. Neurological Disorders: Trials and Tribulations -- 6.1 Brain and Spinal Cord Injuries -- 6.2 Neurodegenerative Disorders -- 6.3 Neuropsychiatric Disorders -- 6.4 Successes, Failures, Hopes -- 7. Diagnosis and Recommendations -- 7.1 Four Perspectives on Models in Biology -- 7.2 Recommendations -- 7.3 Conclusion -- Appendix -- References -- Index
요약"Instead of arguing for a specific animal model, Striedter will review the history and philosophy of animal models in biomedical research, examining their various advantages and limitations"--
일반주제명Animal models in research.
Animal experimentation.
Animal Experimentation
Mode?les animaux dans la recherche.
Expe?rimentation animale.
Animal experimentation.
Animal models in research.
언어영어
기타형태 저록Print version:Striedter, Georg F., 1962-Model systems in biology.Cambridge, Massachusetts : The MIT Press, [2022]9780262046947
대출바로가기https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3160177

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