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Room Temperature Chemoselective Phosphine Oxide Reduction and Mechanism-Based Inhibitors of BioA
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Eiden, Carter G. |
| 단체저자명 | University of Minnesota. Medicinal Chemistry. |
| 서명/저자사항 | Room Temperature Chemoselective Phosphine Oxide Reduction and Mechanism-Based Inhibitors of BioA. |
| 발행사항 | [S.l.] : University of Minnesota., 2017 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2017 |
| 형태사항 | 344 p. |
| 소장본 주기 | School code: 0130. |
| ISBN | 9780438170346 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Courtney Aldrich. |
| 요약 | The reduction of phosphine oxides with silanes occurs with high specificity and fidelity and represents one of the most useful methods for synthesis of phosphines. The chemoselectivity of this process also allows for in situ recycling of phosph |
| 요약 | Abnormal patterns in the reduction rates of phosphetane oxides by phenylsilane were noted, causing initiation of a comprehensive investigation of silane-mediated phosphine oxide reduction which revealed widespread misunderstandings of the reduct |
| 요약 | Mechanism-based inhibitors (MBIs) are widely employed in chemistry, biology, and medicine due to their exquisite specificity and sustained duration of inhibition. The global kinetic parameters kinact and KI have been used to characterize MBIs, b |
| 요약 | 1 inactivates tubercular BioA through a four-step mechanism, and kinetic analysis revealed the rate-limiting step is the removal of the alpha-proton of 1. This knowledge was subsequently applied to rationally design dihydro-4-pyranone 42, dihydr |
| 일반주제명 | Chemistry. Biochemistry. Organic chemistry. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14996596 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028936 | 540 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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