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Post-translational Regulation of XPC in Repair of UV-Induced DNA Damage
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Shah, Palak. |
| 단체저자명 | The University of Chicago. Pathology. |
| 서명/저자사항 | Post-translational Regulation of XPC in Repair of UV-Induced DNA Damage. |
| 발행사항 | [S.l.] : The University of Chicago., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 98 p. |
| 소장본 주기 | School code: 0330. |
| ISBN | 9780438084186 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Yu-Ying He. |
| 요약 | Ultraviolet (UV) radiation from sunlight is a major etiologic factor for skin cancer, the most prevalent cancer in the U.S., as well as premature skin aging. In particular, UVB radiation causes formation of specific DNA damage photoproducts betw |
| 요약 | Here, we show that ubiquitin-specific peptidase 11 (USP11) positively regulates NER by deubiquitinating xeroderma pigmentosum complementation group C (XPC) and promoting its retention at the DNA damage sites. In addition, UV irradiation induces |
| 요약 | We also found that phosphorylation of XPC acts as a novel post-translational regulatory mechanism of the NER pathway. We show that XPC is phosphorylated at serine 94. Moreover, after UVB irradiation, XPC phosphorylation regulates recruitment of |
| 요약 | Our findings have uncovered USP11 and XPC phosphorylation at S94 as novel post-translational regulators of XPC activity in NER, and have significantly increased our understanding of the molecular regulatory mechanisms of UV-induced DNA damage re |
| 일반주제명 | Molecular biology. Cellular biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-11B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14997722 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00027319 | 574 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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