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Mass Spectrometry-Based Characterization, Quantitation, and Repair Investigations of Complex DNA Lesions

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자료유형	E-Book
개인저자	Groehler, Arnold, IV.
단체저자명	University of Minnesota. Medicinal Chemistry.
서명/저자사항	Mass Spectrometry-Based Characterization, Quantitation, and Repair Investigations of Complex DNA Lesions.
발행사항	[S.l.] : University of Minnesota., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	388 p.
소장본 주기	School code: 0130.
ISBN	9780438031272
일반주기	Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. Adviser: Natalia Y. Tretyakova.
요약	DNA is constantly under the threat of damage by various endogenous and exogenous agents, leading to the structural modification of nucleobases (DNA adducts). These DNA adducts can range from smaller nucleoside monoadducts and exocyclic adducts,
요약	DNA-protein cross-links (DPCs) are ubiquitous, super-bulky DNA lesions that form when proteins become irreversibly trapped on chromosomal DNA. The structural complexity of cross-linking and the diversity of proteins susceptible to DPC formation
요약	In Chapter 2, we investigated DPC formation after exposure to N,N-bis-(2-chloroethyl)-phosphorodiamidic acid (phosphoramide mustard, PM) and N,N-bis-(2-chloroethyl)-ethylamine (nornitrogen mustard, NOR), the two biologically active metabolites o
요약	In Chapters 3, we employed the model of left anterior descending artery ligation/reperfusion surgery in rat to show that ischemia/reperfusion injury is associated with the formation of hydroxyl radical-induced DNA-protein cross-links (DPCs) in c
요약	Finally, we investigated the formation of formamidopyrimidine (FAPy) adducts after exposure to 3,4-epoxybutene, an epoxide metabolite of the known carcinogen 1,3-butadiene (Chapter 5). We successfully synthesized and structurally characterized a
요약	In summary, during the course of this Thesis, we utilized mass spectrometry-based proteomics techniques to identify the proteins susceptible to PM- and ROS-induced DPC formation. After structurally characterizing the atomic connectivity of these
일반주제명	Analytical chemistry. Toxicology. Chemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-10B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14997307