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Characterizing Heterogeneity in the Regenerative Capacity of Human Muscle Progenitor Cells

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개인저자Riddle, Emily Suzanne.
단체저자명Cornell University. Nutrition.
서명/저자사항Characterizing Heterogeneity in the Regenerative Capacity of Human Muscle Progenitor Cells.
발행사항[S.l.] : Cornell University., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항174 p.
소장본 주기School code: 0058.
ISBN9780438344129
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Anna Thalacker-Mercer.
요약Skeletal muscle regeneration following muscle damage is imperative to maintain skeletal muscle structure and function throughout the lifespan. Regeneration requires a complex series of events including activation of skeletal muscle specific stem
요약To evaluate the age- and sex-related differences in expansion capacity of primary hMPCs, we compared markers of expansion between young and old, male and female primary hMPC cultures. hMPCs from older males have reduced expansion capacity compa
요약Using K-means cluster analysis and measurements of culture population doubling time and saturation density, we are the first to unbiasedly cluster cultures with similar growth parameters and to identify drivers of expansion capacity that weren't
요약Acute inflammation following muscle injury is essential to activate satellite cells. However, chronic muscle inflammation likely contributes to impaired regenerative capacity in skeletal muscle. Previous research has identified muscle inflammato
요약This dissertation highlights the heterogeneity that exists between humans throughout the muscle regenerative process. Uncovering the molecular underpinnings of this heterogeneity is essential as the field of medicine moves towards a personalized
일반주제명Nutrition.
Physiology.
Molecular biology.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000144

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