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Stroma-Targeting Therapies and Local Intervention in Pancreatic Ductal Adenocarcinoma

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자료유형	E-Book
개인저자	Elahi-Gedwillo, Kianna Y.
단체저자명	University of Minnesota. Biomedical Engineering.
서명/저자사항	Stroma-Targeting Therapies and Local Intervention in Pancreatic Ductal Adenocarcinoma.
발행사항	[S.l.] : University of Minnesota., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	139 p.
소장본 주기	School code: 0130.
ISBN	9780438353442
일반주기	Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. Adviser: Paolo P. Provenzano.
요약	Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest forms of cancer, in part, because it is largely refractory to current therapies. The failure of most standard therapies, as well as promising immune therapies, may be largely as
요약	In Chapter 1, we lay the groundwork to understand the unique pathology of PDA and the relatively recent---and at times, controversial---history of STT. We review the antifibrotic agent, halofuginone (HF), which is utilized in the majority of the
요약	In Chapter 2, the experimental methods used to conduct these studies are described in detail, including the genetically-engineered KPC mouse model our lab employs and the associated intervention studies that these mice were enrolled in.
요약	In Chapter 3, we present the results of our effort to disrupt the severe biophysical barriers characteristic of PDA through stromal re-engineering. This was largely done using the potent antifibrotic agent, HF. In an autochthonous, genetically e
요약	In Chapter 4, we explored the therapeutic potential of local intervention in PDA through IRE. PDA is unable to be treated by a majority of focal therapies used in the clinic, such as heat-based radiofrequency, due to the sensitivity of the pancr
요약	In Chapter 5, we summarize our findings and conclusions, discussing the broader implications of these results. Finally, we outline the future directions that these studies ought to go in. The experiments outlined are expected to flesh out the me
일반주제명	Oncology. Therapy. Biomedical engineering.
언어	영어
기본자료 저록	Dissertation Abstracts International80-01B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14999663