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Clinical Insights from Mouse Models of Breast Cancer

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자료유형	E-Book
개인저자	Rennhack, Jonathan Paul.
단체저자명	Michigan State University. Physiology - Doctor of Philosophy.
서명/저자사항	Clinical Insights from Mouse Models of Breast Cancer.
발행사항	[S.l.] : Michigan State University., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	208 p.
소장본 주기	School code: 0128.
ISBN	9780438148017
일반주기	Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. Adviser: Eran R. Andrechek.
요약	Breast cancer presents an enormous public health concern. One out of eight women will experience breast cancer in her lifetime. To understand the root of breast cancer initiation and progression, many multi "-omic" projects have been undertaken.
요약	To begin to address this critical need, we started by identifying genomic copy number alterations (CNAs) in 600 tumors across 27 major mouse models of breast cancer through the application of a predictive algorithm to publicly available gene exp
요약	Due to the predictive nature of the previous study, we have completed whole genome sequencing and transcriptome profiling of two widely used mouse models of breast cancer, MMTV-Neu and MMTV-PyMT. This genomic information was integrated with phen
요약	To functionalize this data, we followed up on one key amplification event that we found on chromosomes 11D. We identified this event to be associated with worse distant metastasis free survival due to the presence of Co11a1 and CHAD within the a
요약	Here we also identified a conserved mutation in phosphotyrosine receptor phosphatase type H (Ptprh). The mutation is highly conserved in mouse models of breast cancer and is identified to be mutant in 81% of MMTV-PyMT tumors. A key finding is th
요약	Through these studies we have identified key genomic alterations within mouse models of breast cancer. Both of the explored events serve as biomarkers of treatment response and could change the course of therapy for patients. We believe that the
일반주제명	Physiology.
언어	영어
기본자료 저록	Dissertation Abstracts International79-11B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14999498