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Longitudinal Cerebrospinal Fluid Biomarkers of Alzheimer Disease: Movement Toward the Diagnosis, Prognosis and Staging of Disease

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자료유형	E-Book
개인저자	Sutphen, Courtney.
단체저자명	Washington University in St. Louis. Biology & Biomedical Sciences (Neurosciences).
서명/저자사항	Longitudinal Cerebrospinal Fluid Biomarkers of Alzheimer Disease: Movement Toward the Diagnosis, Prognosis and Staging of Disease.
발행사항	[S.l.] : Washington University in St. Louis., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	194 p.
소장본 주기	School code: 0252.
ISBN	9780355555387
일반주기	Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B. Advisers: Anne M. Fagan
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	Alzheimer's disease (AD) is a devastating neurodegenerative disease that slowly claims the memories and experiences that comprise the life experiences of individuals that suffer from the disease. Despite a continually accelerating pace of resear
요약	One important aspect of AD treatment is identification. It is now recognized that the disease begins more than a decade before the signature symptoms of cognitive impairment become apparent. Identifying individuals in this "preclinical" disease
요약	Biomarkers, indicators of normal biological or pathological processes that may be studied as a means to give individuals a disease diagnosis, prognosis, or theragnosis -- provided a treatment is available for the disease in question -- are of pa
요약	The current work begins with an overview of biomarker modalities used in AD
요약	The ACS cohort is comprised of middle-aged, cognitively normal individuals recruited on a volunteer basis from community dwelling participants with and without a family history of AD. The ADNI cohort is comprised of older individuals also recrui
요약	In both cohorts, it was found that CSF markers of amyloid plaques -- one of two required pathological hallmarks that indicate AD -- changed earlier than those of tau tangles, the second required pathological hallmark.
요약	Currently, examining biomarkers on a group-wide basis is the best way to get an accurate picture of biomarkers at baseline and followup lumbar punctures (LPs). As the goal is to be able to give individual people a diagnosis and prognosis of thei
일반주제명	Neurosciences.
언어	영어
기본자료 저록	Dissertation Abstracts International79-05B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996798