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Molecular Insight into the Structure, Function, and Regulation of Bile Acid Transport

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자료유형	E-Book
개인저자	Czuba, Lindsay Christine.
단체저자명	University of Maryland, Baltimore. Pharmaceutical Sciences.
서명/저자사항	Molecular Insight into the Structure, Function, and Regulation of Bile Acid Transport.
발행사항	[S.l.] : University of Maryland, Baltimore., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	183 p.
소장본 주기	School code: 0373.
ISBN	9780355591248
일반주기	Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B. Adviser: Peter W. Swaan.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	The human Apical Sodium-dependent Bile Acid Transporter (SLC10A2), also known as hASBT, plays an integral role in the enterohepatic circulation of bile acid and cholesterol homeostasis. As a member of the solute carrier family of membrane transp
요약	Limiting the development of such therapeutics, is an incomplete understanding of hASBT's structure. Extensive biochemical and mutagenesis studies for hASBT support a seven transmembrane model. Yet conflicting structures have emerged with the elu
요약	In this work we provide novel molecular insight into the structure, function, and regulation of human ASBT. We contrasted the biochemical, inhibitory, and evolutionary attributes of nmAsbt, yfAsbt, and hASBT and identified their critical differe
요약	Additionally, we characterized the role of tyrosine phosphorylation in regulating the functional expression and stability of hASBT. We identified Src family kinases as critical modulators and provide support for hASBT's regulation by phosphatase
요약	Finally, we have optimized the biological sample preparation methods and have significantly increased the purity of hASBT samples. When coupled with mass spectrometry analysis, these methods will identify critical proteoforms of hASBT and facili
일반주제명	Pharmaceutical sciences.
언어	영어
기본자료 저록	Dissertation Abstracts International79-05B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996722