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Mechanisms of Protein Localization in Cryptococcus neoformans Mediate Virulence and Immune Recognition

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자료유형	E-Book
개인저자	Esher, Shannon Kimberley.
단체저자명	Duke University. Molecular Genetics and Microbiology.
서명/저자사항	Mechanisms of Protein Localization in Cryptococcus neoformans Mediate Virulence and Immune Recognition.
발행사항	[S.l.] : Duke University., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	246 p.
소장본 주기	School code: 0066.
ISBN	9780355870220
일반주기	Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B. Adviser: J. Andrew Alspaugh.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	Cryptococcus neoformans is an opportunistic fungal pathogen that causes significant disease and death in immunocompromised populations, in particular among those with advanced HIV infection. This fungus is found ubiquitously in the environment a
요약	Fungal growth and morphogenesis, as well as thermotolerance and virulence are controlled by conserved Ras-like GTPases. These proteins require proper localization for full function and are directed to cellular membranes through the posttranslati
요약	C. neoformans dramatically alters its cell wall upon entering the host in order to facilitate immune avoidance. Using the tools of forward genetics, we identified a novel cell wall regulatory protein, Mar1. We have demonstrated that this protein
요약	To further understand the impact of the Mar1 protein on the host-pathogen interaction, we used in vivo mouse models to characterize the pathogenesis and immune response to this strain. Using histopathology and light microscopy, we have shown tha
요약	Lastly, using bioinformatics tools and batch sampling, we developed a novel computational tool to more efficiently analyze mutants of interest generated by forward genetic screens. We demonstrate the efficacy of this tool through proof of princi
일반주제명	Microbiology. Genetics. Molecular biology.
언어	영어
기본자료 저록	Dissertation Abstracts International79-09B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996929