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Characterization of Receptor Use and Entry Mechanisms in Two KSHV Infection Systems

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개인저자TerBush, Allison Alwan.
단체저자명University of California, Berkeley. Molecular & Cell Biology.
서명/저자사항Characterization of Receptor Use and Entry Mechanisms in Two KSHV Infection Systems.
발행사항[S.l.] : University of California, Berkeley., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항129 p.
소장본 주기School code: 0028.
ISBN9780438325173
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Laurent Coscoy.
요약Viruses initiate infection at the cell surface, where they use viral proteins to contact and manipulate naturally occurring host receptors in the plasma membrane. Through this interaction, viruses negotiate internalization and begin their infect
요약Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an important human pathogen. It is the causative agent of several cancers and inflammatory disease which together, in the context of the global HIV epidemic, are a major public health burden. KSH
요약Here we investigated KSHV receptor usage in cell types that are relatively understudied in the field: epithelial cells and lymphocytes. We uncovered novel variability in receptor use across many susceptible cell lines, particularly that infectio
요약Furthermore, we showed that coculture-mediated infection of BJAB cells required heparan sulfate and Eph receptor interactions, despite the fact that BJAB cells do not express heparan sulfate and manipulation of Eph receptor expression did not af
요약Our work reveals another layer of complexity beyond receptor availability on cells. It is now clear that even when KSHV receptors are expressed by a cell, additional contextual factors determine whether they play a role during infection. Going f
일반주제명Virology.
Cellular biology.
Microbiology.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14998405

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