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Architects of structural biology : Bragg, Perutz, Kendrew, Hodgkin / [electronic resource]

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자료유형E-Book
개인저자Thomas, J. M. (John Meurig), author.
서명/저자사항Architects of structural biology :Bragg, Perutz, Kendrew, Hodgkin /John Meurig Thomas.[electronic resource]
판사항First edition.
발행사항Oxford, United Kingdom ; New York, NY : Oxford University Press, 2020.
형태사항1 online resource
소장본 주기OCLC control number change
ISBN9780192596710
0192596713
9780191888793
0191888796


일반주기 Includes index.
요약Designed for the non-specialist, the explanations and illustrations used here describe the work, personalities, collaborations, and idiosyncrasies of four of the most distinguished Nobel Laureates of the twentieth century. They exploited a discovery made over a century ago about the nature of X-rays, and thereby created a new branch of science. This enabled them to elucidate, in atomic detail, the structure and mode of action of molecules of the living world: enzymes, vitamins, and viruses, as well as antibiotics. Perutz and Kendrew, from their pioneering work using X-ray diffraction on haemoglobin and myoglobin, the proteins that transport and store oxygen in all animals, led them to establish in 1962 one of the most successful research centres ever - the Laboratory of Molecular Biology (LMB) in Cambridge. Medicines discovered there are used worldwide to treat leukaemia, arthritis, and other diseases. Their work also led to the creation in the United States of the Protein Data Bank that guides scientists in understanding the misfolding of proteins, which cause Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. This book is first a memoir of these scientists and their contemporaries, many of them friends of the author. Second, it is an insight into the great excitement associated with structural molecular biology, which directly informs our understanding of ourselves. Third, it describes how two renowned research centres in the United Kingdom - the LMB and the Davy-Faraday Research Laboratory - achieved iconic status. It also highlights the importance of the popularization of science, of which Bragg, Perutz, and Kendrew, as well as Dorothy Hodgkin (who solved the structures of penicillin and vitamin B12) were experts.
주제명(개인명)Bragg, William Henry,1862-1942.
Perutz, Max F.
Kendrew, John C.(John Cowdery), -- 1917-1997.
Hodgkin, Dorothy,1910-1994.
Bragg, William Henry,1862-1942. -- fast --
Hodgkin, Dorothy,1910-1994. -- fast --
Kendrew, John C.(John Cowdery), -- 1917-1997. -- fast --
Perutz, Max F.fast --
주제명(단체명)Laboratory of Molecular Biology -- History.
일반주제명Scientists -- Great Britain -- History -- 20th century.
Molecular biology -- History -- 20th century.
Proteins -- Structure -- Research -- History -- 20th century.
Molecular biology.
Scientists.
주제명(지명)Great Britain. -- fast
언어영어
기타형태 저록Original01988545019780198854500
대출바로가기https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=2375977

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